The treatment of true erythrocytosis, or true erythrocytosis, is mainly aimed at relieving symptoms and avoiding blood clots. Common treatments include symptomatic treatment, venous bloodletting, thrombosis prevention, and hypocellular therapy. 1. Symptomatic treatment, the disease often manifests as itching and gouty arthritis. Itchy people can use cyproheptadine, high uric acid people can take oral purinol. 2. Intravenous bloodletting, for true erythrocytosis, can also choose intravenous bloodletting treatment. This treatment can quickly relieve symptoms, and is not easy to induce aberrations and other tumors, but also can make the headache symptoms improved. 3. Thrombosis prevention, embolism is the main cause of death in patients with true erythrocytosis, so the prevention of thrombosis is very important, the first choice of medicine aspirin, intolerant patients can choose dipyridamole. 4. Cell-lowering therapy, for high-risk patients, platelets greater than 1500 × 10^9 / L, intolerant to intravenous bloodletting, progressive splenomegaly, progressive leukocyte hyperintensities should receive cell-lowering therapy. Common methods include drug therapy, interferon therapy, and radionuclide therapy. There may be other treatments for true erythrocytosis, and it is recommended to visit the hospital in time for standardized treatment under doctor’s guidance. Doctor’s medication needs to be used under doctor’s supervision.