Cold sweat after 12 o’clock in the middle of the night may be a physiological phenomenon; it can also be a symptomatic manifestation of certain diseases, such as myocarditis, arrhythmia, etc., and should be promptly diagnosed to find out the cause of the disease. 1. Physiological phenomenon: heartbeat after 12 o’clock in the middle of the night cold sweat may be mental stress, overwork and other physiological factors, relaxation and rest can generally be relieved. 2. Disease factors: (1) myocarditis: for patients with myocarditis leading to the above symptoms, there is currently no specific treatment. It is generally recommended to ensure adequate sleep and avoid late nights. Corresponding medication can also be selected according to the patient’s arrhythmia symptoms, such as amiodarone and sotalol. (2) Arrhythmia: Arrhythmia patients may manifest as heartbeat weakness after 12 o’clock in the middle of the night, patients can follow the doctor’s instructions to take anti-arrhythmic drugs, such as procainamide, lidocaine and other drugs for treatment. After 12 o’clock in the middle of the night heartbeat weakness cold sweat need to consult a doctor in time to identify the cause, for treatment.