Acute attacks of gouty arthritis can usually be relieved after 1 to 2 weeks, even without treatment. However, repeated attacks of gouty arthritis can lead to joint deformities and gouty stone formation, and can also turn into chronic gouty arthritis. Therefore, the earlier the medication is used during an acute attack of gouty arthritis, the better the results. The main drugs for acute attacks of gouty arthritis are: Colchicine: 1.0mg for acute attacks of gouty arthritis, followed by 0.5mg one hour later; after 12 hours, if necessary, another 0.5mg. After that, take 0.5mg twice or three times a day, for a total of no more than 1.5mg daily until the pain symptoms are relieved, usually no more than two weeks. Application within 24 hours of onset is effective, but patients with renal insufficiency should follow medical advice to adjust the dose. In addition, colchicine and some drugs can affect each other. If you are taking colchicine while using other drugs, you should consult your doctor first. Preventive use of colchicine: The process of uric acid-lowering treatment often triggers gout attacks. This has become an obstacle that affects patients’ adherence to uric acid-lowering treatment, and many patients give up uric acid-lowering treatment as a result. It is recommended to start using colchicine 2 weeks before uric acid-lowering treatment for gout. The dose of colchicine should be determined according to the duration and frequency of gout attacks in patients, and may be 0.5 mg once or twice daily. colchicine needs to be used simultaneously with uric acid-lowering treatment for 6 to 12 months. Precautions for taking colchicine: If vomiting or diarrhea occurs, the dosage should be reduced and the drug should be stopped immediately in serious cases; use with caution in patients with bone marrow hematopoietic insufficiency, severe heart disease, renal insufficiency and gastrointestinal disorders; blood picture and liver and kidney function should be checked regularly during the drug administration; female patients need contraception during the drug administration and within six months after stopping the drug. Non-steroidal anti-inflammatory drugs (NSAIDs): The key to successful treatment of acute attacks of gout is to start an NSAID therapy as soon as possible. These drugs should be taken with a meal to reduce gastrointestinal side effects, and a concomitant gastric protector may be used in the event of gastric distress. Traditional NSAIDs often cause side effects such as gastrointestinal bleeding and kidney damage, including indomethacin and ibuprofen. The new NSAIDs have significantly lower gastrointestinal adverse effects, and their clinical efficacy is no less than that of traditional drugs, but they may all have cardiovascular side effects, so patients with combined cardiovascular disease should choose carefully. Celecoxib and etoricoxib are new NSAIDs that are more commonly used, especially etoricoxib, which has strong analgesic strength and light gastrointestinal reactions, and is one of the recommended NSAIDs for acute attacks of gout. glucocorticoids: glucocorticoids can rapidly relieve pain and reduce congestion and edema in joints, but they are prone to relapse after discontinuation, so they are only used for patients with very severe and recurrent gout symptoms, and should not be It should not be used for a long time. Therefore, when the acute inflammation of gout is limited to one or two joints, it is better to choose local intra-articular injection of hormone. In addition, it is best to use hormones in combination with colchicine to avoid relapse after discontinuation of the drug; however, avoid combining with non-steroidal anti-inflammatory drugs as much as possible to avoid aggravating the damage to the gastric mucosa. Other precautions: In acute attacks of gout, bed rest, elevation of the affected limbs, and avoid weight-bearing on the affected joints should also be taken. Avoid the intake of purine-rich foods, strictly limit alcohol consumption, pay attention to the warmth of the affected limbs, avoid getting cold, and do not use creams such as rheumatic pain relief cream without authorization. For patients with asymptomatic hyperuricemia, prevention of gout attacks is based on non-pharmacological treatment, mainly including dietary control and alcohol cessation, avoiding drugs that raise blood uric acid such as diuretics, small doses of aspirin, compound antihypertensive tablets, pyrazinamide, nifedipine and propranolol. If blood uric acid is still higher after dietary control (>420 μmol/L (7.0 mg/dl) in men and postmenopausal women and >350 μmol/L (5.8 mg/dl) in premenopausal women), use uric acid-lowering drugs. For intermittent patients who have had acute gouty arthritis, the key to prevent the reoccurrence of gout is to control the blood uric acid level to the standard through diet and medication, in addition to avoiding strenuous exercise or injury, controlling body weight, drinking more water, and alkalizing urine for a long time.