Diabetic foot is a general term for a group of peripheral neuropathy and peripheral vascular disease, with various clinical manifestations, among which peripheral vascular stenosis and occlusion are only suitable for endovascular intervention, which rapidly restores the blood supply to the lower limbs, which is the key to the treatment of diabetic foot. For those with significant stenosis, regardless of the early or late stage, interventional therapy has very good efficacy in restoring blood supply. Currently, interventional therapy mainly includes endovascular thrombolysis, balloon dilatation angioplasty, stent implantation, thrombus rotary cutting and aspiration, endoluminal vascular ultrasound ablation, thrombectomy, and so on. Perioperative glycemic control of interventional procedures to avoid the occurrence of infection. During the interventional procedure, appropriate catheters and guide wires are used to pass through the stenotic segment, expand and ablate by balloon, and if necessary, stent implantation opens the lower limb vessels, restores distal peripheral blood supply, and relieves the related clinical symptoms caused by ischemia. Post-interventional rehabilitation of diabetic foot is crucial because of the high incidence of vascular restenosis after intervention, which should be strictly controlled by blood glucose, oral antiplatelet and anticoagulant drugs to improve microcirculation. Anti-infection helps to protect vascular patency and relieve symptoms.