Glucocorticoid drugs, there is a characteristic adverse drug reaction is rebound phenomenon, refers to the process of hormone withdrawal, if the dosage is reduced too quickly or suddenly stop the drug, it will lead to rapid reappearance or aggravation of the original symptoms of the disease. Therefore, if patients with nephrotic syndrome suddenly stop using hormones, it will lead to disease aggravation or relapse. For patients with nephrotic syndrome, the use of glucocorticoids should follow the following principles of use: first, should start in full, in full use of 8-12 weeks when the drug can be effective, some patients can be extended to 16 weeks; second, slow reduction of the drug, after full treatment every 2-3 weeks to reduce the original amount of 10%, when the reduction of the minimum dose needs to be maintained for a long time; third, long-term maintenance, the application of the smallest dose of drugs should be maintained for a period of time, to avoid the disease. when applying the minimum dose of the drug should be maintained for a further period of time to avoid the possibility of disease recurrence.