Glucocorticoid-induced osteoporosis is a typical drug-related secondary osteoporosis. The pathogenesis of this disease is that glucocorticoids can stimulate the activity of osteoclasts to increase and inhibit the activity of osteoblasts, which will gradually lead to the onset of osteoporosis. The use of glucocorticosteroids also inhibits calcium absorption, leading to metabolic disorders of proteins, electrolytes and other nutrients in the body, aggravating osteoporosis. For patients using glucocorticoids for a long period of time, it is important to routinely supplement calcium and return to the orthopedic department for regular checkups to determine if there is any such disease. Once these patients experience low back pain and obvious weakness, they must return to the orthopedic department in time for a follow-up examination to clarify whether osteoporosis has occurred.