Children with fever and hot hands and feet does not necessarily mean that the disease is almost over, but may also be in a period of persistent high fever. Fever is a clinical symptom triggered by an increase in heat production under the action of a pyrogen or a dysfunction of the body temperature center, which is mostly related to infection, metamorphosis, and malfunction of the thermoregulatory center. Fever can be divided into the period of rising temperature, persistent high fever and falling temperature. In the period of rising temperature, the child’s body temperature will rise, accompanied by fear of cold, cold hands and feet and other symptoms, while in the period of persistent hyperthermia, the child’s hands and feet will be feverish, accompanied by accelerated respiration, accelerated heart rate and other phenomena, and the body temperature can be sustained for a period of time unchanged. If the disease is almost over, i.e. in the period of decreasing body temperature, the child will also show fever in the hands and feet. Therefore, based on the fever of the hands and feet alone, can not accurately determine whether the fever is almost over, children with fever is recommended to consult a doctor in a timely manner, in accordance with the doctor’s instructions for standardized treatment and treatment.