The development of laryngeal squamous cell carcinoma has not been fully clarified yet, and it may be related to smoking, alcohol consumption, air pollution, occupational factors, sex hormones, lack of trace elements and other reasons. 1. Smoking: it is one of the important independent risk factors of squamous cell carcinoma of the larynx. Tobacco will produce smoke tar after burning, and the benzo(a)pyrene contained therein has certain carcinogenic effect, which may lead to the development of squamous cell carcinoma of the larynx. 2. Alcohol consumption: the probability of laryngeal squamous cell carcinoma is higher in those who drink alcohol than those who do not. 3. Air pollution: sulfur dioxide, dust, arsenic and other substances produced by industry may lead to the development of laryngeal squamous cell carcinoma. 4. Occupational factors: occupations that require long-term exposure to toxic chemicals, such as asbestos, mustard gas, etc., may also suffer from squamous cell carcinoma of the larynx. 5. Sex hormone: some researches show that testosterone level of laryngeal cancer patients will be higher than normal people, and estrogen will be lower, but the level of testosterone will be decreased obviously after removing the tumor. 6. Lack of micronutrients: lack of micronutrients may cause changes in the structure and function of enzymes, affecting the growth and division of cells, and gene mutation, leading to laryngeal cancer. Those who have the above factors are recommended to go to the hospital for consultation to clarify the specific causes and follow the doctor’s instructions for treatment if necessary.