Cholesteatoma is most often removed surgically because it is basically a benign tumor in the skull and is not particularly sensitive to radiotherapy or chemotherapy, and there is no drug that can be taken orally to eliminate cholesteatoma. Therefore, the majority of cholesteatomas are removed surgically. However, the specific surgical approach should be decided according to the specific morphology and location of the cholesteatoma, because the morphology of intracranial cholesteatoma is relatively complex and has many locations, and it can be removed through frontal approach, temporal approach, or even through posterior sigmoid sinus. Therefore, a preoperative examination should be performed to determine the exact location of the cholesteatoma, its shape, and whether it encircles any blood vessels or nerves. In some cases, a combination of both surgical procedures is required to remove the cholesteatoma, so that the specific changes in the condition can be clarified to facilitate the removal process.