Brain inflexibility, excluding congenital IQ factors and age factors, can also be considered chronic hypoxia of brain cells, cerebrovascular lesions, poor mental health, etc. 1, chronic hypoxia of brain cells: chronic hypoxia of brain cells will lead to gradual decline in brain cell function, attention can not focus, and in severe cases, there will be slow reaction, inflexible mind, slow thinking, etc.. The cause is mainly atherosclerosis, or anemia caused by a decrease in the content of hemoglobin, cellular oxygen-carrying capacity, also seen in chronic poisoning or carbon monoxide poisoning resulting in brain cell hypoxia, or long-term hypoxic environment, low pulmonary ventilation, etc., the specific need to confirm the diagnosis according to the examination; 2, cerebrovascular lesions: due to cerebral infarction or cerebral hemorrhage, the patient’s brain function is impaired, appearing slow reaction, memory loss, mental inflexibility, etc. Memory loss, mental inflexibility, also known as vascular dementia in severe cases; 3, poor mental: sleep disorders, mental anxiety, tension can also damage the brain, manifested as weakness, memory loss, mental inflexibility, etc., and in severe cases, amnesia can occur. For this condition, lifestyle changes are the main focus, and if necessary, oral medications to improve brain nerve function, such as brain protein hydrolysates, can be taken as prescribed by the doctor; 4, other causes: visible intracerebral tumors or trauma compression, damage to the brain nerve tissue.