Inhibitory effect of morphine on respiration

Morphine is mainly used clinically to treat the severe pain of cancer, but while treating pain, it also has the side effect of inhibiting the body’s breathing. Morphine can inhibit the body’s respiratory movement, which can slow down the respiratory rate significantly, reduce the ventilation of the lungs, and the intensity of breathing will also be reduced. The main reason for this is that morphine reduces the sensitivity of the respiratory center of the brainstem to carbon dioxide in the blood, which further inhibits the respiratory center of the cerebral bridge, and the respiratory function of the body forms an anesthetic state, thus accelerating the development of hypoxia in the body. This is even accompanied by a large amount of carbon dioxide retention in the body, causing hypercapnia, combined with hypoxemia, which may seriously lead to respiratory failure.