The obstruction of food passage in the stomach is due to lesions such as ulcers or cancerous tumors. It can be divided into two main categories: incomplete obstruction and complete obstruction. Pyloric obstruction is one of the common complications of gastric and duodenal ulcers and can occur in the recent (i.e., active) or late stage of ulcer disease. Prevention of food passage obstruction in the stomach due to gastric ulcer: 1. Smoking The incidence of ulcer disease is two times higher in smokers than in nonsmokers, and smoking affects ulcer healing and can promote ulcer recurrence by the following possible mechanisms: (1) Smoking can contribute to increased secretion of gastric acid and pepsinogen. (2) Smoking may inhibit the secretion of HCO3-salt by the pancreas, thereby impairing the ability to neutralize acidic fluid in the bulb. (3) Smoking may affect the closing function of the pyloric sphincter and lead to bile reflux and damage the gastric mucosal barrier; smoking may delay gastric emptying and affect gastroduodenal motility. (4) Smoking can affect the synthesis of prostaglandins in the gastroduodenal mucosa, reducing the amount of mucus and mucosal blood flow, thus reducing the defense function of the mucosa. 2, diet Wine, coffee, strong tea, Coca-Cola and other beverages can stimulate increased secretion of gastric acid, which can easily induce ulcer disease. Those who eat refined low-fiber foods have a higher incidence of ulcers than those who eat high fiber. It is thought that multi-crumb foods may have the role of promoting the release of epidermal growth factor or prostaglandins. 3, mental factors Long-term mental stress, anxiety or mood swings in people prone to ulcers. When a person is in a stressful state, it may promote the secretion and motor function of the stomach, increase the secretion of gastric acid and accelerate the emptying of the stomach, while the sympathetic excitement makes the gastroduodenal vasoconstriction, mucosal blood flow decreases, weakening the mucosa’s own defense function. 4, drugs long-term oral non-steroidal anti-inflammatory drugs about 10% to 25% of patients with ulcer disease, which is more common with gastric ulcer. In addition to the direct stimulating effect of drugs on the gastroduodenal mucosa, mainly due to the inhibition of cyclooxygenase activity in the body of such drugs to reduce the synthesis of prostaglandins in the mucosa, weakening the protective effect on the mucosa. Aspirin prodrugs are fat-soluble and can penetrate the epithelial cell membrane to destroy the mucosal barrier.