Patients with cold and painful bone symptoms, the following common causes: 1, osteoarthritis: mainly related to degenerative changes, joint blood circulation is impaired and manifested as synovial inflammation, the patient will have symptoms of bone pain, accompanied by chills, usually accompanied by joint stiffness, joint range of motion will be significantly reduced, taking X-rays will find joint degeneration, osteophytes, joint space narrowing, the patient 2, lower limb artery stenosis: such as lower limb plaque formation, can cause the narrowing of the lumen of the blood vessels, insufficient blood supply to the arteries will cause the clinical symptoms of cold pain in the bones of the lower limbs, insufficient blood supply will stimulate the nerves, causing pain symptoms continue to worsen, and the skin temperature will continue to decrease, through the vascular ultrasound examination can find the location of the lesion and the extent of the lesion.