Dry syndrome is a chronic inflammatory autoimmune disease that mainly involves a variety of exocrine glands, with clinical manifestations such as dry mouth and eyes, which can be improved with medication such as cyclophosphamide, azathioprine and other immunosuppressants. Artificial tears and artificial saliva can be used to improve the symptoms of dry mouth and eyes. Smoking, alcohol consumption and drugs that cause dry mouth should be stopped and oral hygiene should be maintained. Immunosuppressants such as cyclophosphamide and azathioprine can inhibit abnormal immune responses in the body and improve extra-glandular symptoms such as arthritis and interstitial lung disease. All of the above medications should be used as prescribed by your doctor. If dry syndrome is diagnosed, early and standardized treatment is recommended to minimize the adverse effects of the disease.