Herniated disc is a common disease, the current treatment can be mainly divided into two categories of conservative treatment and surgical treatment, more than 80% of patients can receive results through conservative treatment. If the effect of conservative treatment is not good, surgical treatment can be considered. With the progress of science and technology, surgery is becoming more and more minimally invasive, the traditional open surgery has been gradually reduced, replaced by a variety of interventional minimally invasive treatment. Ozone nucleolysis is an interventional minimally invasive treatment for herniated disc introduced in Europe. Due to the strong oxidizing property of ozone and its anti-inflammatory and analgesic characteristics, it can effectively oxidize and shrink the herniated disc, and has the least side effects among the current minimally invasive disc treatments, making it a highly effective, safe and effective method of herniated disc eradication. Ozone (O3) consists of an oxygen molecule (O2) with an oxygen atom (O), which is extremely unstable and is one of the strongest oxidizing agents known to be available. Ozone has been used for medical purposes for many years. With the in-depth study of basic medical theories, ozone therapy, as an ancient but innovative method, is being recognized by more and more medical practitioners, and there is an ozone therapy society in almost every country. Ozone therapy for lumbar disc herniation first appeared in Italy. Italy siena university bocce professor from the 1980s that is on the mechanism of ozone action of a large number of basic research. Research shows that O3 has anti-inflammatory, analgesic and dissolve the role of proteoglycans in the nucleus pulposus, etc. In 1988, the Italian doctor VERGA firstly injected ozone into the lumbar psoas muscle and the paraspinal space to treat lumbar and leg pain; in the mid-90’s, Muto and others injected ozone into the intervertebral discs and paraspinal space to treat lumbar disk herniation and reported in 1998, the effective rate is 80.9%. The mechanism of ozone mainly includes the following aspects: 1, oxidation of proteoglycans in the nucleus pulposus: O3 is a strong oxidizing agent, its oxidizing ability is second only to fluorine, and its half-life is 20 minutes at room temperature. It can rapidly oxidize the proteoglycans in the nucleus pulposus after injection into the intervertebral disc, so that the osmotic pressure of the nucleus pulposus decreases, water is lost, and denaturation, drying, necrosis and atrophy occur. Animal experiments show that the dog lumbar intervertebral disc in the injection of O2 – O3 gas mixture 1 month after the nucleus pulposus dry, 2 ~ 3 months is obvious atrophy, necrosis, while the simple O2 injection group has no obvious changes. The use of O3 of this property, to achieve the purpose of making the protruding nucleus pulposus retraction, nerve root compression relief. 2.Anti-inflammatory effect: the prominent nucleus pulposus and fibrous ring compress the nerve root and its surrounding veins, resulting in periapical neuritis and venous return obstruction, edema, oozing. In addition, glycoproteins and β-proteins released after the breakage of fibrous rings act as antigenic substances, causing the body to produce an immune response, forming aseptic inflammation and serious adhesions, which are the main causes of low back pain.The anti-inflammatory effect of O3 is to antagonize the release of immune factors in the inflammatory response, dilate the blood vessels, improve the venous return, and alleviate the oedema of the nerve root and the adhesion, thus achieving the purpose of relieving pain. To achieve the purpose of pain relief. 3, analgesic effect: O3’s analgesic effect is still directly on the surface of the intervertebral disc, adjacent ligaments, small joints and lumbar muscle widely distributed nerve endings, these nerve endings are activated by the inflammatory factors and prominent nucleus pulposus of the chemicals released (such as substance P or phosphatase A2, etc.), causing reflexive lumbar spasms and cause low back pain. Overseas scholars have also used O2-O3 gas mixture intramuscular injection of the lumbar large muscle for the treatment of lumbar muscle strain. Some scholars speculate that the use of fine needles to puncture the intervertebral disc can produce similar to the “chemical acupuncture” effect, can stimulate the inhibitory intermediate neurons to release substances such as enkephalin, so as to achieve the purpose of analgesia. This may also explain why some patients experience short-term symptomatic relief after O2-O3 gas mixture injections into the intervertebral discs and paravertebral spaces.