Many sugar friends reflect that after insulin, blood sugar control, but people are getting fat, how to do? This may in fact be due to good blood sugar control, the normal increase, but also may be one of the side effects of insulin, for obvious gain, what should we do? 1, insulin selection has a trick: deuterated insulin does not increase weight. Studies have shown that dextro insulin is not only able to control blood glucose equally effectively, but also reduce hypoglycemia and weight gain compared to zinc fisetin insulin. The principle is supposed to be that Dieter’s insulin enters the brain more easily and increases the insulin concentration in the brain, thus suppressing the appetite center of the hypothalamus, reducing the feeling of satiety, and reducing the amount of food eaten, avoiding weight gain. 2, as far as possible to minimize the amount of insulin: to learn to use diet and exercise to adjust the amount of insulin, so that blood glucose can be controlled at the same time as the minimum amount of insulin. Adjustment of insulin dosage for obese or emaciated patients is different, e.g., when blood glucose does not reach the standard, obese people should firstly reduce the amount of diet and increase the amount of exercise instead of increasing the insulin dosage. Lean people should first increase the amount of insulin rather than reduce the amount of diet. 3, insulin combined with oral medication: obese type 2 diabetes can be combined with medication, such as insulin plus metformin, insulin plus α-glucosidase inhibitors can be avoided in combination with weight gain. 4, lipid regulating drugs are effective for weight gain: for different types of dyslipidemia, lipid regulating drugs should be actively used, as long as the lipids can be controlled in the target range, even if the weight is not reduced, the cardiovascular risk caused by obesity will be significantly reduced. Correct conditioning, it is completely possible to achieve good glycemic control and no weight gain.