The symptoms of pre-depression often do not have the three low symptoms typical of depression, which are low affect, lack of interest, and diminished pleasure, and are often dominated by somatic symptoms or other additional symptoms. The main symptoms of pre-depression are: 1, cognitive function is reduced, the patient’s attention may not be focused, memory is reduced, thinking is slower, speaking is slower and voice is lower. 2, there may be a state of psychomotor inhibition or excitement, the patient may show a slower reaction, learning, work efficiency is lower or slightly reduced, some patients can also show too much attention to one thing, or 3. In daily life, patients may have poor sleep, such as difficulty falling asleep or waking up early. The patient’s diet may increase or decrease significantly, and the patient’s weight may change accordingly. The patient’s sexual function may be affected, such as loss of libido.