Whether or not thyroid nodule 4b surgery can be completely cured cannot be generalized, and needs to be judged according to the nature of the patient’s nodules. Thyroid nodules are a common clinical disease, usually due to long-term iodine deficiency in the patient’s body, the presence of family history of the disease and other reasons. According to the degree of malignancy of thyroid nodules under imaging, they are categorized into grades 1 to 6, among which, grade 4 thyroid nodules are further categorized into grades 4a, 4b, and 4c. Grade 4b thyroid nodules have a certain degree of malignancy, with a risk of about 10% to 50%. Whether grade 4b thyroid nodules can be completely cured by surgery cannot be generalized, but depends on the actual nature of the patient’s nodules. Patients can first seek medical attention to determine the nature of the nodule through a puncture biopsy of the nodule. If the nodule is determined to be benign, it can usually be completely cured through surgical treatment such as total thyroidectomy. However, if the nodule is found to be malignant, early treatment may still lead to a complete cure, but if the treatment is not timely, the nodule may develop into thyroid cancer, which is more difficult to be cured completely. It is recommended that patients with grade 4b thyroid nodules should consult a doctor as soon as possible to clarify the nature of the nodules and choose the appropriate treatment according to their actual condition under the guidance of the doctor.