It is usually possible to get pregnant during the hepatitis B vaccination, but it is recommended that pregnant couples ask their doctor for guidance on their situation. Hepatitis B vaccine is mainly a special medicine to prevent infection with hepatitis B virus. When the body is vaccinated, it will stimulate the immune system so as to produce protective antibodies. If the body is inadvertently infected by the hepatitis B virus, the antibodies will sterilize the virus, thus stopping the infection, in order to achieve the purpose of preventing hepatitis B infection. Generally speaking, pregnancy can be normal during hepatitis B vaccination, and the vaccine will not affect the growth and development of the fetus. However, due to the variability of individual constitution, it is recommended that couples who have the need to get pregnant can ask their doctor’s opinion, and if the doctor does not recommend getting pregnant during the period, they need to follow the doctor’s advice to delay the pregnancy. During the period of hepatitis B vaccination, it is necessary to keep the local skin clean to avoid secondary infection. Meanwhile, patients should ensure sufficient rest time, do not overwork or stay up late for a long time.