How long should I take clopidogrel after drug-eluting stent implantation? The results of current studies on this question are inconsistent and controversial. Most studies show no additional benefit from taking clopidogrel for more than 1 year over just 1 year, and some studies show benefit from taking it for more than 1 year, which may be related to the wide variation in study enrollment populations, where most low-risk patients are safe and reasonable to stop after 1 year, and certain high-risk patients may benefit from taking clopidogrel for more than 1 year or even longer, and the current studies mix these populations together, potentially leading to one reason for the conflicting results. Physicians may have different opinions about which patients need to be on clopidogrel for longer periods of time.