Atherosclerotic thrombosis is a continuous overall disease that involves the arterial vessels supplying different organs or systems and can lead to transient ischemic attacks and strokes, angina pectoris, myocardial infarction and sudden cardiac death, atherosclerotic nephropathy, and intermittent claudication. If a patient has a first episode of myocardial infarction, he has a 4-6 times increased risk of future myocardial infarction and a 3-4 times increased risk of stroke; if a patient’s first event is a stroke, he has a 9 times increased risk of future stroke and a 2-3 times increased risk of myocardial infarction; if a patient has peripheral atherosclerotic disease, whether he has intermittent claudication or not, he If a patient has peripheral atherosclerotic disease, regardless of whether he has intermittent claudication, he has a 4-fold increased risk of myocardial infarction and a 2-3 times increased risk of stroke. Therefore, the disease is in the legs, but the risk is in the heart and brain. Carotid intima-media thickness (IMT) is associated with stroke, but IMT is also a very important predictor of myocardial infarction. Peripheral atherosclerotic thrombosis is of concern because it has a poor prognosis, with a five-year mortality rate equal to that of colon cancer or non-Hodgkin’s disease. Peripheral atherosclerosis is an equivocal risk for coronary artery disease. If a patient has lower extremity atherosclerosis, then his statin intervention to lower LDL cholesterol should be at least 100 mg/dl, the same as that required for patients who already have coronary artery disease, and these different sites of atherosclerotic thrombosis have common risk factors, and intervention of these risk factors will not only reduce myocardial infarction, but also have a beneficial effect on systemic arterial vascular intervention of these risk factors will not only reduce myocardial infarction but also have a multi-bird effect on the prevention of systemic arterial disease. Whether it is peripheral atherosclerosis or coronary atherosclerosis, elevated blood cholesterol, diabetes, hypertension and smoking are common risk factors. Small amounts of alcohol (equivalent to no more than 10 grams of alcohol per day, i.e. 250 ml of beer, 100 ml of wine or 50 ml of white wine) may be protective factors, but large amounts of alcohol can raise blood pressure, cause atrial fibrillation and even lead to myocardial infarction or strokes. The prognosis of peripheral atherosclerosis is that 2-4% require amputation after about 10 years of follow-up, but a very important cause of death is coronary artery disease, with 55% of deaths ultimately due to coronary artery disease and 10% due to cerebrovascular disease. Of particular concern is that asymptomatic patients with lower extremity atherosclerosis can also affect prognosis. The ankle-brachial index (ABI) is a very suitable test for early detection of lower extremity atherosclerotic disease in some high-risk groups, is non-invasive, and is as easy as a blood pressure test; it helps to confirm the diagnosis of peripheral arterial disease with 95% sensitivity and 99% specificity. It helps to identify patients at high risk for cardiovascular disease. The mortality rate increases as the ABI value decreases. Atherosclerotic thrombosis of the lower extremities is a disease of the elderly, and according to US data, one in five patients over 65 years of age has peripheral atherosclerosis, while only one in 10 patients has symptoms of intermittent claudication, so it needs to be emphasized that the absence of symptoms is not necessarily without risk. It is more important to intervene in asymptomatic patients so that they do not suffer myocardial infarction not coronary heart disease not stroke death. It is very unfortunate that we lack these epidemiological evidences in our country. The American Diabetes Association clearly recommends that all patients with greater than diabetes who have these risk factors of smoking, hypertensive disease, dyslipidemia or a history of diabetes for more than 10 years should be routinely screened for ABI.