The choice of the time period for oral administration of antihypertensive medications needs to be determined by the duration of onset of action of the medication. If the drug is to be taken orally only once a day, it can be taken orally in the morning and in the evening. If the drug is taken orally twice a day, it should be taken in the morning and in the afternoon between 4:00 and 6:00 pm, because there are certain peaks and valleys of blood pressure fluctuations in the human body within 24 hours. Generally, 6-9 a.m. and 4-6 p.m. in the morning are at a peak blood pressure value, so in this case, two oral doses of the drug should be taken during these two periods, which can assist in strengthening the blood pressure, and try not to take the drug too late at night. But if it is a daily oral medication, such as Bexin, Irbesartan, Valsartan, Hydrochlorothiazide tablets, etc., you can choose to take it in the morning or in the evening, because this drug is 24 hours of continuous slow-release antihypertensive.