Bile reflux is somewhat related to anxiety. Bile is secreted by the liver and empties into the duodenum through the bile ducts. If the patient is affected by some factors and the bile drains into the stomach in a retrograde manner, it is called bile reflux. Patients with bile reflux should be aware of any gallbladder, bile duct, and stomach related problems that may be causing the reflux. If related disorders are ruled out and the patient has severe anxiety, and the symptoms of bile reflux worsen after anxiety, a clear correlation with anxiety can be considered. Anxiety can lead to disorders in the patient’s neurological function, resulting in an imbalance of sympathetic and parasympathetic functions throughout the body, causing disorders in the gastrointestinal function, which can lead to abnormal bile excretion, resulting in bile reflux. In addition, if bile reflux is caused by organic factors, anxiety may also aggravate the symptoms of bile reflux. Since anxiety can cause patients to develop bile reflux, they should pay attention to actively combat anxiety in their daily life. They can perform appropriate sports and exercise and do more soothing things, such as listening to music and taking a walk, which are effective in combating anxiety. If bile reflux occurs, it is recommended to go to the hospital for examination in time, and some drugs can be used for treatment, such as drugs promoting gastrointestinal dynamics, including mosapride citrate, and at the same time add drugs inhibiting gastric acid, such as lansoprazole or rabeprazole, etc. for treatment.