When aspirin is allergic, you can consider replacing it with drugs such as cyclooxygenase inhibitors (e.g., indobufen), antiplatelet aggregation drugs (e.g., clopidogrel hydrogensulfate, tegretol), and phosphodiesterase inhibitors (e.g., cilostazol, dipyridamole).1. Cyclooxygenase Inhibitors: Aspirin is one kind of cyclooxygenase inhibitor, except that aspirin is an irreversible cyclooxygenase inhibitor, and there are one kind of reversible cyclooxygenase inhibitors, the main representative drug is indobufen. Because of the evidence-based medicine of aspirin confirms that its benefit is more clear, and indobufen because of the lack of evidence-based medicine and other reasons and less used, but for aspirin allergy population, can consider using under the guidance of a doctor; 2, antiplatelet aggregation drugs: its representative drugs are mainly hydroclopidogrel and tegretol, in the guidelines for acute coronary syndromes, it is recommended that the patient in the aspirin based on the co-prescription of hydrochloropidogrel and tegretol. clopidogrel and tegretol, or they can be used alone. There is also tirofiban hydrochloride can be used instead of aspirin, but because of half-life utilization and other reasons, no oral preparation, generally need to be pumped intravenously, so the replacement of aspirin may not be as convenient as the first two mentioned above; 3. Phosphodiesterase inhibitors: the main cilostazol and bispyrimethamine, the clinical evidence suggests that there is insufficient prognostic benefit for coronary artery disease and that bispyrimethamine can also exacerbate myocardial ischemia, so these drugs are not commonly used, only as an alternative drug for patients who cannot tolerate aspirin, not the first choice.