Herpes next to the mouth is divided into herpes simplex or herpes zoster, which is treated as follows: 1. For herpes simplex can be left alone and can have a tendency to heal on its own. If the rash is dense and distributed in clusters, accompanied by severe pain, it can be treated with oral valacyclovir hydrochloride, famciclovir, and topical acyclovir ointment, with a cycle of about 7 days to heal. 2. Herpes zoster, caused by varicella-zoster virus infection, can be accompanied by severe neuralgia, with the rash occurring unilaterally next to the mouth. In terms of treatment, if it is more serious, you can order acyclovir injection, or ganciclovir injection quietly. If it is not severe, you can take oral antiviral drugs as mentioned above, and you need to take oral mecobalamin capsule type of nerve-nourishing drugs. And for severe pain, you can take oral pregabalin capsules for pain treatment.