The difference between tinea pedis and impetigo lies in the following aspects: 1. Site of onset: tinea pedis occurs on the back of both feet, on the soles of the feet, and between the toes, while impetigo usually occurs on the heart of both hands and on the fingers. 2. Rash pattern: in addition to blisters, tinea pedis can also be seen as keratinization, chapping, hypertrophy, vesicles, maceration, and exudation, while impetigo usually appears as small, round blisters with clear fluid inside. 3. Clinical treatment In terms of tinea pedis, antifungal treatment with topical ciclopirox ointment is needed, and sweat blister requires antiallergic treatment with topical hydrocortisone butyrate ointment.