AOSC refers to acute obstructive septic cholangitis, which is a very serious acute abdominal condition in clinical practice. It is caused by bile duct obstruction and bacterial infection resulting in increased pressure in the bile ducts, and a large number of bacteria and toxins enter the blood circulation, resulting in sepsis, azotemia, hyperbilirubinemia, toxic hepatitis, and systemic inflammatory response syndrome, which can result in short-term, life-threatening multi-organ failure. Acute obstructive septic cholangitis is mainly seen in patients with bile duct stones and history of previous biliary surgery, and clinically it mainly manifests as high fever, chills, abdominal pain, jaundice, and there will be shock and central nervous system inhibition, such as oliguria, anuria, drowsiness and even coma, which is also known as Raynaud’s Pentad. When acute obstructive septic cholangitis occurs in the clinic, first of all, rapid antishock treatment should be given, sodium bicarbonate should be applied to correct metabolic acidosis, and broad-spectrum sensitive antimicrobial drugs should be selected for combined application. On the basis of non-surgical treatment, timely surgical, endoscopic or interventional treatment should also be performed to reduce the pressure in the bile duct. For the presence of bile duct stones, bile duct stenosis, you can also wait for the condition to stabilize, and then elective surgical treatment.