There is no so-called “best” treatment for adult mycoplasma pneumonia, we need to choose the appropriate program according to the disease, mainly symptomatic, anti-infective treatment. Mycoplasma pneumonia is a pneumonia caused by atypical pathogens, which mostly occurs in children and adolescents, but is also more common in adults, and is mainly characterized by a severe dry cough. Mycoplasma pneumonia is self-limiting, and most cases can be cured without treatment. Appropriate medication can shorten the duration of the disease and reduce symptoms. Symptomatic treatment mainly involves the use of drugs such as cotrimoxazole capsules to suppress coughing, and physical hypothermia and ibuprofen for those with fever. Anti-infective treatment mainly applies erythromycin and other macrolide antibiotics, and those who are not sensitive to macrolides can use levofloxacin and other fluoroquinolones. There is no best treatment plan for adult mycoplasma pneumonia, and it needs to be analyzed and treated according to the condition. Different symptoms of the patients will lead to different symptomatic treatment plans, and different antibiotic sensitivities will also require the use of different antibiotics. It is recommended that patients consult a doctor in a timely manner, choose the appropriate treatment plan, and use the medication under the guidance of a physician.