Mycoplasma pneumoniae is an acute inflammatory change in the respiratory tract, caused by Mycoplasma pneumoniae infection. The course of treatment usually takes 2~3 weeks, and it is normal to apply azithromycin for one day without significant improvement. Mycoplasma pneumoniae is a self-limiting disease, and early use of antibiotics can reduce symptoms and shorten the course of the disease. Commonly used macrolide antibiotics, such as erythromycin, azithromycin, etc., the course of treatment is about 2 to 3 weeks. However, it takes 72 hours to evaluate the efficacy of antibiotics, so if azithromycin is not effective for one day, it can be continued and evaluated after 72 hours. In addition, for people with severe cough, cough suppressants can be given appropriately, which can assist in relieving cough symptoms; if azithromycin is still ineffective in the later assessment, levofloxacin, moxifloxacin, and other anti-infective treatments can be replaced. Mycoplasma pneumoniae has a better prognosis, standardized treatment can reap better results, and should actively cooperate with the doctor’s treatment.