High liver function, total bilirubin, direct bilirubin and low indirect bilirubin may be due to physiological factors such as staying up late at night, or pathological factors such as intrahepatic or extrahepatic obstructive diseases. 1. Physiological factors: If there are recent bad habits such as staying up late, overwork, alcoholism, etc., it will cause transient damage to liver cells, which may cause high liver function, total bilirubin, direct bilirubin, and low indirect bilirubin. 2. Intrahepatic obstructive diseases: such as primary cholestatic cirrhosis, due to biliary stasis, affecting the excretion of direct bilirubin, and at the same time there is a certain degree of damage to hepatocytes, which may cause transaminases and other liver function indexes to rise, so that the patient has liver function, total bilirubin, direct bilirubin is high, and indirect bilirubin is not high. 3. Extra-hepatic obstructive diseases: such as bile duct stones, gallbladder stones, biliary tract tumors, etc., also block the bile ducts, affecting the excretion of bile into the intestines, so that the level of direct bilirubin rises, which may also have an impact on liver function, resulting in high liver function, total bilirubin, direct bilirubin, and indirect bilirubin is not high. If patients have long-term or recurrent high liver function, total bilirubin, direct bilirubin, and low indirect bilirubin, it is recommended that they seek medical attention to identify the cause of the disease and carry out targeted treatment to avoid delaying the condition.