With progesterone, you will normally have a normal menstrual flow within 14 days. If you have progesterone and no menstruation for more than 14 days, you need to have a sex hormone test and gynecological ultrasound. The sex hormone test will help to understand the ovarian function of the patient. If the patient’s ovarian function suggests postmenopausal changes, further hormone replacement therapy is required. Before hormone replacement therapy, gynecological examination is required to exclude contraindications before proceeding. If the progesterone has been administered for more than 14 days and there is no menstruation, if it is caused by the endometrium, such as damage to the endometrium caused by abortion, or if the patient has tuberculosis, which causes destruction of the endometrium. In this case, if the patient’s endocrine and sex hormone six tests are normal and ovulation is normal, no special treatment is needed for this condition.