Toothache is a common disease that many people have encountered in their lives, while lingual-pharyngeal neuralgia has a low incidence, and because of this, many patients with “non-toothache” are often misdiagnosed as “toothache” when they visit the clinic. We have encountered many such unfortunate patients in our clinical practice. These patients often consult the stomatology department because of facial pain or tooth root pain, and are treated with tooth extraction, and all the teeth that can be extracted are removed, but the pain still exists. In fact, there are obvious points of differentiation between toothache and the above two types of neuralgia if carefully identified. The main difference is that toothache is often dull and persistent, and local inflammation or tooth decay is often seen on examination. In contrast, trigeminal neuralgia and glossopharyngeal neuralgia are sharp stabbing pains, discharge-like in nature, often intermittent, and stopping as normal. The site of glossopharyngeal neuralgia is often on one side of the tongue, throat, tonsils, root of the ear and the back of the jaw, while trigeminal neuralgia is mainly located on one side of the face. Trigger points are often present on the face, and triggering the trigger point can often trigger a painful episode. Again, the two aforementioned pains are effective with carbamazepine, while toothache is ineffective. These disorders are still relatively easy to identify through careful diagnosis. It is recommended here that when the above symptoms exist, you must go to a regular general hospital and do not take palliative care, but must first confirm the diagnosis and then treat it. Don’t try to save your time, often spending money and delaying the treatment, so that the disease will not be cured.