Liver discomfort with high aspartate aminotransferase may be related to acute and chronic viral hepatitis, alcoholic liver disease, cirrhosis and other liver diseases. Aspartate aminotransferase is abundantly distributed in the mitochondria of the liver, and in the case of liver discomfort, may be primarily related to liver disease. For example, acute viral hepatitis generally has significant elevation of both aspartate aminotransferase and alanine aminotransferase, and chronic viral hepatitis may be mildly elevated; frequent alcohol drinkers may be due to alcoholic liver disease; long-term medication users may be associated with medication-induced hepatitis; and fatty liver, cirrhosis, hepatocellular carcinoma, and other liver disorders may also cause high aspartate aminotransferase. In addition, aspartate aminotransferase is distributed in large quantities in the myocardium, and its high level may also be related to acute myocardial infarction. When there is liver discomfort and high aspartate aminotransferase, further examination should be conducted under the guidance of a doctor to clarify the cause for active treatment.