Nucleic acid test can be done for cold and sore throat. Cold and sore throat can also do nucleic acid test, there is no effect on the nucleic acid test results, and in the nucleic acid test, it will not directly irritate the throat, and will not aggravate the condition, but only a slight discomfort, usually about 3~5 minutes can be relieved by themselves, you can rest assured that you can do. However, if you are worried that a sore throat from a cold will affect the sensitivity of the nucleic acid test, you can also do a nasal swab directly. The secretion from this area carries more virus than the throat, and the test results will be a bit more accurate. If you do the nucleic acid test when you have a cold and sore throat be sure to inform your doctor, who will adjust the test appropriately according to your personal situation or reduce the strength of the test, which can effectively alleviate the adverse reaction.