Calluses on the hands may be formed by callus, chronic eczema or keratosis pilaris, and it is recommended that patients be treated with medication under the guidance of a doctor. 1. Callus: hand skin long-term extrusion or friction may form callus. Patients can use warm water to soak their hands to soften the keratin, and then externally use Vitamin A acid ointment, salicylic acid ointment and other exfoliating drugs. 2. Chronic eczema: chronic eczema is usually due to acute eczema progression, patients can use mometasone furoate, compound clobetasol propionate cream or urea ointment under the guidance of the doctor to improve. 3. Keratosis pilaris: Keratosis pilaris is caused by fungal infections, it is recommended that the patient under the guidance of a doctor to use topical antifungal drugs, such as ketoconazole, clotrimazole ointment, or the use of keratolytic agents such as compound benzoic acid, and in severe cases can be orally itraconazole and other drugs. The above drugs need to be used in accordance with medical advice. For patients with calluses on the hands, it is recommended to go to the regular hospital for examination, clear diagnosis, standardized treatment under the guidance of the doctor.