Hepatic lobe atrophy is a common symptom of liver abnormality, which is caused by the long-term or repeated action of one or more etiologies, resulting in diffuse liver damage. Clinically, it can be asymptomatic in the early stage due to strong liver function compensation; in the later stage, there is multi-system involvement, with liver function impairment and portal hypertension as the main manifestations, and serious complications such as gastrointestinal bleeding, hepatic encephalopathy, secondary infection and carcinoma often occur. The diagnosis of hepatic lobe atrophy is mainly based on several aspects, including medical history, clinical manifestations, liver function tests, and imaging examinations. 1. Medical history: Whether there are possible causes of hepatic lobe atrophy. For example, history of hepatitis, history of alcohol consumption, history of drugs, history of blood transfusion, social history and family history of genetic disease. 2, clinical manifestations: according to the above clinical manifestations of patients with hepatic lobe atrophy to determine the presence of portal hypertension and liver dysfunction manifestations. 3.Liver function test: Decreased serum albumin, increased bilirubin and prolonged prothrombin suggest liver function loss. 4.Imaging: The above-mentioned ultrasound and CT are helpful for the diagnosis of hepatic lobe atrophy. In conclusion, a complete diagnosis of hepatic lobe atrophy should include four parts: etiology, pathology, function and complications.