The causes of redness, swelling and pain in the palm of the hand are infection, tenosynovitis, allergy and so on. 1. Infection: caused by staphylococcus aureus, hemolytic streptococcus and other infections, there can be local inflammation in the palm of the hand, often manifested as elevated skin temperature, localized swelling, pain, often need amoxicillin, cephalosporin and other antimicrobial drugs for treatment, and need to be punctured and drained when there is pus. 2. Tenosynovitis: long-term hand work industry, due to excessive friction between the tendon and the muscle sheath can produce acute and chronic aseptic inflammation, tendon sheath tissue edema, combined with infection, can be manifested as obvious redness, swelling, local pain, limited joint activity and other symptoms, can be relieved by drug therapy, local closure, surgical treatment. 3. Allergy: when contact with rubber, irritating food, chemicals, etc., can be allergic to cause contact dermatitis, manifested as local redness, swelling, blisters, pain, etc., need to carry out anti-allergy drug therapy, can be used externally with glucocorticosteroids, can also be taken orally with loratadine capsules and other anti-allergy. When the palms of the hands are red, swollen and painful, you need to consult a doctor in time to clarify the cause of the disease and then targeted treatment. The use of the above drugs should be in accordance with medical advice.