Quadruple drug treatment of Helicobacter pylori general course of treatment for 14 days, 14 days after the symptoms will improve the bacteria will mostly disappear. Helicobacter pylori is the main cause of peptic ulcer and recurrence of the disease, eradication of Helicobacter pylori positive clinically commonly used quadruple drug treatment, that is, inhibit gastric acid secretion of drugs (omeprazole), 2 antimicrobial drugs (clarithromycin, amoxicillin) and bismuth (bismuth potassium citrate), but the choice of drugs should be in accordance with the doctor’s instructions. The eradication rate of H. pylori positivity can be 80% to 90% with a rational combination of drugs and an adequate course of treatment (usually 14 days). All of the above medications should be administered under the guidance of a medical professional. If any of the above situations occurs, please consult a doctor in time for reasonable and standardized treatment.