Primary central diffuse large b-cell lymphoma can be treated with chemotherapeutic drugs such as methotrexate, cytarabine, etc. Radiation therapy is also available. 1. Chemotherapy: this disease belongs to a kind of malignant disease, patients can control the proliferation of tumor cells by injecting chemotherapeutic drugs, common drugs mainly include methotrexate, cytarabine and so on, during the period of using drugs, patients need to follow the doctor’s instruction strictly, and need to pay attention to the changes of the body. 2. Radiotherapy: Radiotherapy can reduce the size of tumor to control the condition and improve the quality of life of patients, such as whole brain and spinal cord radiotherapy. During the treatment period, patients should pay attention to their own changes and take relevant treatment measures under the guidance of physicians if they have any obvious discomfort.