High intraocular pressure has been unable to come down, can be used under the guidance of a doctor to relieve the symptoms of Trichostatin Nitrate Eye Drops, Timolol Maleate Eye Drops and other drugs, the more serious condition can be taken trabeculectomy and other surgical methods to treat. 1. Hirsutine nitrate eye drops: usually is a kind of parasympathomimetic drugs, generally through in primary open-angle glaucoma, contraction of ciliary body before and after the longitudinal muscles, pulling over the iris protrusion and trabecular meshwork, can be contraction of the pupil sphincter produces pupil shrinkage, pull the iris closer, so that the accumulation of the periphery of the anterior chamber angle of the iris out of the anterior wall of the anterior chamber angle to promote the decline of intraocular pressure. 2. Timolol maleate eye drops: generally refers to the adrenergic receptor blocker, can inhibit atrial aqueous production, so as to achieve the effect of lowering intraocular pressure. It can be applied to the treatment of glaucoma, high intraocular pressure and other diseases. Long-term overuse may cause stinging, insomnia, drowsiness and other uncomfortable symptoms. 3. Surgery: If the intraocular pressure is too high and has not been able to come down, surgery such as trabeculectomy can also be taken to treat it. In daily life, you should pay attention to avoid excessive eye use and participate in outdoor activities appropriately. High intraocular pressure that does not go down is a very serious condition, so it is important to consult a doctor in time, follow the doctor’s instructions for medication and treatment, and not self-medication.