Knee pain may be caused by sports strain injury due to strenuous exercise, degenerative knee disease, trauma and other reasons, the most effective treatment includes physical methods, medication assistance and surgical treatment. 1. Exercise strain: ice packs after strenuous exercise can effectively relieve knee pain; too much exercise may accelerate the aging of the knee joint, it is recommended to change to mild sports, such as slow walking, tai chi, etc.; usually can also be on the knee heat therapy, massage, etc., to ease the soft tissue fatigue around the knee joint. 2. Knee degenerative disease: mainly manifested as osteoarthritis of the knee, you can choose medication for adjuvant treatment, such as oral ibuprofen, meloxicam and other pain relievers; intra-articular injection of sodium vitrate to increase joint lubrication. The above drugs should be used under the guidance of a doctor to avoid self-medication. 3. Trauma: Trauma to the knee joint may cause structural abnormalities within the knee joint, and some patients require surgical intervention, such as patients with cruciate ligament ruptures and meniscus tears. Surgical modalities include knee arthroscopy for ligament repair and reconstruction, meniscoplasty and suturing. Specific surgical procedures need to be decided based on the patient’s primary condition. If knee pain is not relieved, or accompanied by other symptoms, patients should go to the hospital in time, to identify the cause and then give targeted treatment.