Splenic fibrosis is mostly caused by splenocyte damage, and usually has symptoms such as anemia and fatigue. In the early stage of splenic fibrosis, due to the small extent of necrosis and the small number of damaged cells, there are usually no obvious symptoms. With the further progression of splenic fibrosis, the necrotic cells gradually increase, and due to autoimmune reaction, the patient will have fever, and with the necrosis of splenic cells, the fibrotic tissues proliferate, and the function of the spleen becomes abnormal, and the spleen is unable to make blood normally, and the immune system decreases, which will result in severe anemia, malaise, and other discomforts. When patients with splenic fibrosis, it is important to complete spleen ultrasound and spleen puncture examination as soon as possible to clarify the cause of splenic fibrosis, and timely treatment to avoid disease progression and delay of the disease.