The majority of people in clinical practice suffer from low self-esteem and depression due to the unattractive appearance of cranial defects. In fact, the harm caused by cranial defect is far more than that, the integrity of the cranial cavity is seriously damaged after the defect, the intracranial environment and intracranial pressure become very unstable, which will directly affect the circulation of cerebrospinal fluid and blood in the patient’s cranium; in addition, the normal operation of brain nerve function may also be affected, thus causing a series of cranial defect syndrome, for example, the patient will feel dizzy and headache, limb numbness, weakness, easy to irritability, and also vision, hearing and smell disorders. For example, patients may feel dizziness and headache, numbness of the limbs, easy to be irritable, and also have vision, hearing and smell impairment, and in serious cases, epilepsy may be induced. Cranial defects should not be ignored, and timely cranial repair is the first task to solve the problem. Cranioplasty is a routine procedure in neurosurgery to remedy cranial defects. It has been continuously practiced clinically and proved to be effective in improving cranial defect syndrome, so it is said that cranioplasty helps to restore neurological function. Many patients with cranial defects accompanied by dizziness and headache have significantly reduced their symptoms after the surgery. In addition, there are some patients with motor disorders and psychological disorders before the repair, who gradually return to normal life after the repair, so it is significant to have cranial bone repair. Titanium mesh material has the disadvantage of producing more discomfort after surgery, which has deterred many people. At this time, polyetheretherketone peek material was born to bring new life to patients with cranial defects. Our team chose peek as the implant material and added the innovative plastic concept to ensure a beautiful and natural appearance after surgery, and achieved very good clinical results.