Sulfonylurea hypoglycemic agents are a kind of hypoglycemic drugs commonly used in clinical practice, and their mechanism of action is as follows: First, sulfonylureas bind to sulfonylurea receptors on pancreatic β-cells, thus promoting insulin secretion, so sulfonylurea hypoglycemic agents work by promoting insulin secretion, and are only applicable to type 2 diabetic patients whose pancreatic β-cells are still functional, and are not applicable to type 1 diabetes. Second, sulfonylurea hypoglycemic agents can reduce the platelet aggregation rate and fibrinolytic system activity. Sulfonylurea hypoglycemic agents can be used in combination with a variety of oral drugs such as biguanide preparations, glycosidase inhibitors and insulin sensitizers. However, sulfonylureas work by promoting insulin secretion, so there is a possibility of hypoglycemia either alone or in combination, so sulfonylureas oral drugs need to be applied reasonably under the guidance of doctors.