Pylorus positive 2 plus sign means that it represents the infection of Helicobacter pylori, which is a condition of infection and may cause diseases such as atrophic gastritis and gastric ulcer. If not treated in time, it is a serious manifestation that can lead to malignant diseases such as gastric cancer. Checking the appearance of Helicobacter pylori infection, you should promptly choose the quadruple drugs for treatment, that is, two antibiotics with a kind of drugs to inhibit the secretion of gastric acid and a kind of bismuth, such as clarithromycin, amoxicillin, rabeprazole, bismuth potassium citrate and so on. During the treatment of H. pylori infection, life and diet should be regular, quit smoking and drinking, avoid overeating, follow the doctor’s instructions for medication, and regular review. If suspected Helicobacter pylori infection, it is recommended that patients go to the gastroenterology department of the hospital in a timely manner for examination and diagnosis, and the drugs need to be used under the guidance of a professional doctor.