Heart failure generally does not cause low platelet count, if accompanied by low platelet count, it is recommended to go to the hospital for diagnosis and treatment. The most common causes of low platelets are infection, aplastic anemia, leukemia and other blood system diseases or due to medication. 1. Infection: low platelets are caused by infectious factors, the most common of which are viral infections such as cold and flu, rubella virus, etc. It is necessary to carry out anti-infectious treatments according to the original disease, and the platelets in the body will return to normal with the cure of viral infections. 2. Aplastic anemia: due to hypoproliferative bone marrow or severe hypoproliferative bone marrow, the production of blood cells is reduced, which will lead to low platelet, mainly manifested as aggravated anemia, infection and bleeding. Immunosuppressive treatment with anti-lymphocyte/thymocyte globulin, pro-hematopoietic treatment with stanozolol, and symptomatic hemostatic treatment with phenol-sulphonamide should be chosen according to medical advice. 3. Leukemia: Leukemia will cause certain hematopoietic dysfunction, thus causing low platelet count. According to the doctor’s advice, we can use tyrosine kinase inhibitors for drug treatment, or molecular targeting therapy and surgical treatment. 4. Drugs: heart failure patients with low platelets may also be taking antiplatelet drugs for a long time caused by the reduction of platelets, if it is determined to be drug-induced platelet reduction, according to the doctor’s orders to adjust the amount of drugs or replace the drug. It is recommended that patients seek timely medical attention to identify the cause of the disease and comply with the doctor’s instructions on the cause of the treatment, not blindly use drugs.