Blisters are known as blisters. Transparent blisters on the knee may be due to localized soft tissue contusion, burns, contact dermatitis and other factors, and can be relieved by general treatment, medication and other methods. 1. local soft tissue contusion: some patients may be due to accidental fall factors, resulting in local tension blisters, and soft tissue contusion related to the use of povidone-iodine coating, can play a role in sterilization and disinfection, alleviate the patient’s symptoms. 2. Scald: some patients may be accidentally scalded by fire or hot water, resulting in the phenomenon of long transparent blisters on the knee area, can cooperate with the doctor through oral amoxicillin, cefixime, etc., and topical mupirocin ointment, etc., to improve the patient’s symptoms. 3. Contact dermatitis: knee area in contact with allergens or irritants, may be accompanied by local skin allergy or irritation reaction, the formation of blisters and itching symptoms, can be oral loratadine and other antihistamines, thereby reducing the local allergic reaction. It is also important to search for the causative agent and avoid re-exposure. Transparent blisters on the knee may also have other causes, it is recommended to go to the hospital in a timely manner to improve the examination, to clarify the cause of the disease under the guidance of the doctor standardized treatment. The above medications should be used in accordance with the doctor’s instructions.