The clinical manifestations of hemifacial atrophy syndrome: more women than men, generally in late adolescence before 20 years of age, one side of the face from the skin atrophy, gradually extended to subcutaneous fat, fascia, muscle, cartilage and cheek, frontal, upper and lower jaw bone tissue. The lesions generally do not go beyond the midline and are clearly delineated from normal tissues, but often appear as a delineated indentation in the middle of the forehead or slightly off, which is called “saber scar”. The lesion develops chronically and progressively, but can be stopped and stabilized at any stage. Along with tissue atrophy, skin depigmentation or darkening, hair loss or graying, excessive sweating or sweating shutdown, and decreased salivation on the affected side may occur. In individual cases, there is trigeminal neuralgia, facial sensory disturbance on the affected side or seizures. This syndrome is a non-genetic disease, and the cause of its development is not known. There are scleroderma theory, sympathetic nerve disorder theory, trigeminal interstitial neuritis theory, vasomotor trophic nerve theory, and infection theory. However, none of them can be explained completely. Second, the clinical treatment of hemifacial atrophy syndrome There is no effective method to terminate the progression of the disease, therefore, the treatment of hemifacial atrophy is mainly plastic surgery. 1, early treatment: the disease is in the progressive stage, depending mainly on the degree of atrophy. Clinical symptoms are not obvious can be observed and temporarily not treated. If the tissue atrophy is more obvious, you can first do autologous fat particles transplantation. Autologous fat transplantation can effectively improve the patient’s appearance, and at the same time there are no unfavorable factors affecting the later treatment. Until the condition is stabilized, artificial materials should not be implanted in general. Because, if the disease continues to develop, further treatment will be needed, at which time the pre-implants will have an impact and may have to be removed, then the early treatment will be equivalent to wasted money. 2, Phase II treatment: (1) advanced disease, the patient bone tissue, skin muscle and other soft tissue changes are more obvious, need to do bone tissue plastic, then soft tissue plastic. Simple bone tissue plastic, or simple soft tissue plastic can not get better clinical results. (2) The treatment of osteoplasty is mainly referred to orthognathic surgery. If necessary, artificial materials can be implanted. (3) Soft tissue plastic surgery is mainly tissue filling, including autologous fascial fat flap, muscle tissue flap, autologous fat particles filling, etc.. If necessary, artificial materials can be transplanted into it.