Tachyphylaxis does not usually involve profuse sweating at night. Clinically known as amyotrophic lateral sclerosis, acromegaly is a rare disease that is often caused by damage to motor neurons. Motor neurons have the function of controlling muscles, so amyotrophic lateral sclerosis caused by damage to motor neurons affects the normal function and health of the muscles, with symptoms such as muscle weakness, muscle atrophy, difficulty breathing, weakness in chewing, and abnormal muscle throbbing. Sweat is secreted by sweat glands and sweating is controlled by the autonomic nervous system. Amyotrophic lateral sclerosis does not damage the autonomic nerves, so the disease does not usually cause heavy night sweating. Patients with amyotrophic lateral sclerosis who experience heavy night sweating should consider other causes, such as autonomic neuropathy or excessive environmental temperatures, and are advised to seek professional medical help.