Whether ABO hemolytic jaundice in newborns is serious or not, it needs to be judged comprehensively according to various factors such as antibodies entering the body as well as compensatory hematopoietic ability, etc. The specific analysis is as follows. 1. Not serious: if full-term newborns have ABO hemolytic jaundice and the antibodies entering the body are relatively small, it may cause mild hepatosplenomegaly, which usually does not cause other symptoms of bilirubin encephalopathy, and is usually not very serious. 2. Severe: If it occurs in preterm babies and more antibodies enter the body, anemia, hepatosplenomegaly, severe jaundice, etc., accompanied by symptoms of bilirubin encephalopathy such as depression, screaming and convulsions, etc., which are relatively serious. Parents in the discovery of newborns with ABO hemolytic jaundice, the need for timely hospital treatment, basically can be recovered.